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Conditions & Indications

The CyberKnife system is used to treat a great variety of intracranial and extracranial indications. As a general guideline the following conditions and indications are available for procedures:


Radiosurgery is Indicated
  • As an Adjunct or planned "boost" after conventional external beam radiation therapy (XRT)
  • As an alternative to conventional XRT, especially for radioresistant tumors
  • For tumor recurrence in previously irradiated Regions. These patients usually have no other Option.
  • As an alternative to conventional surgery:
    • Equivalent outcomes in some cases
    • Medical condition may preclude surgery
    • Patient preference is a large factor
Benign Tumors
  • Meningioma
  • Pituitary Adenoma
  • Acoustic Neuroma
  • Other Cranial nerve Schwannomas
  • Glomus Jugulare Tumors
  • Residual/recurrent low-grade Astrocytoma Oligodendroglioma, Hemangioblastoma
Malignant Tumors
  • Metastatic Tumors
  • Malignant Gliomas
Vascular Lesions
  • Arteriovenous Malformations (AVM)
  • Cavernous Malformations/AOVM
Functional Disorders
  • Trigeminal Neuralgia
  • Cluster Headache
  • Recurrent or residual head and neck tumors after conventional treatment


  • Selected solitary metastases without bony spinal cord compression
  • Primary treatment of classically radioresistant solitary tumors, i.e. melanoma, renal cell, and sarcoma
  • Recurrent solitary metastases after Conventional radiotherapy
Benign Tumors
  • Stage I NSCLC if medically inoperable or if patient refuses open surgery
  • Advanced state NSCLC as a boost treatment
  • Up-front treatment of obstructing endobronchial lesion with post-obstructive pneumonia
  • Metastases: solitary or limited (2-5) multiple metastases if symptomatic or enlarging on serial imaging with a favorable survival profile
  • Metastases: solitary or limited (2-5) multiple metastases if symptomatic or enlarging on serial imaging with a favorable survival profile
  • Up-front radio surgery treatment of unresectable tumor "sandwiched" between chemotherapy doses
  • Boost treatment for persistent PET-positive region after conventional chemotherapy and radiation therapy
  • Renal cell cancer in medically inoperable patients
  • Low-risk prostate cancer as an alternative to multi-week IMRT, low dose brachytherapy or high-dose brachytherapy (HDR)
  • Fro vaginal cuffs as primary or as boost

Note: Other conditions may be treatable, please consult the CyberKnife Center for a recommendation.

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